I suppose smallpox and malaria and dengue. HIV as well but that is much harder to catch
Smallpox has of course been eradicated because it didn't mutate and the vaccine worked well. Still no vaccine for the others
Prof Sarah says her vaccine worked on monkeys and so should work in the human trials. I have no idea if Covid19 can adapt to counter this synthetic vaccine
Originally Posted by: The Beast from the East
Thanks Beast. Malaria, though not a virus, nicely illustrates some of my concerns. Since the early days of quinine, various new treatments have emerged and some have become obsolete as the parasite became immune to them. To make the most of our defences we attacked on several fronts - the epidemiological triad of host, agent and environment, plus the vector, the mosquito. The environmental action focused on removing pools and water bodies where the mosquito might breed, reducing the possibility of vector to host transmission. Pesticicides were used to kill adult mosquitoes to directly remove the vector. Barriers to the vector were added and improved, mosquito nets, fly-screened doors and windows, plus use of domestic pesticides and repellents. Humans took antimalarials that would kill the parasite. People in malarial areas live daily with such measures.
The position today is "There is currently no commercially available malaria vaccine. Over 20 other vaccine constructs are currently being evaluated in clinical trials or are in advanced preclinical development." "[WHO] "The development of resistance to drugs poses one of the greatest threats to malaria control and results in increased malaria morbidity and mortality. Resistance to currently available antimalarial drugs has been confirmed in only two of the four human malaria parasite species, Plasmodium falciparum and P. vivax." [CDC]
I have never had Dengue - but once lived in a Dengue area. My Dr said - "It is one of my favourite diseases - Breakbone Fever! It will not kill you but you will wish it did. You will recover." The main method of control is to prevent transmission by measures against the vector, the mosquito. As you say - we did manage to eradicate Smallpox through vaccination and public health measures. It's an encouraging story most folks will know.
I'm trying to be optimistic - but the best I can manage is caution. Environmental and behavioral measures are important weapons, but WRT vaccines and therapies I am not going to do optimism yet.
Roger
RogerP West Lindsey district of Lincolnshire
Everything taken together, here in Lincolnshire are more good things than man could have had the conscience to ask.
William Cobbett, in his Rural Rides - c.1830